PURPLE CORN

ANTI TUMORAL
ANTI CANCER
ANTI ANGING

Purple Corn (HerbalGram)
Powerful Antioxidant,anti aging, the most abundant
polyphenolic compounds present.

contains phenolic acids and anthocyanins.

PROPERTIES:

- Improve your night vision
- Hipotensive effect.
- Lipotropic effect.
- Precent The Colon Cancer

SUGGESTED FOR:

- Anti-anging
- Anti Cancer and Anti Tumoral
- Hypertense, High Blood Pressure
- Cholesterol
- Obesity.

Cancer.

Could the anthocyanin pigment prevent some types of cancer specially the malignat amd bening tumors

The anthocyanin pigment works against the carcinogen (PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
mama? That question was put to the test in rats first treated with a carcinogen (1,2-dimethylhydrazine) that also targets the mammary gland, prostate, and large intestine in rats and causes colorectal cancer. Carcinogen is the most abundant of around other types found in cooked meats and fish. Both the early signs of colorectal cancers and the numbers of malignant and benign tumors


Colon cancer is the second most deadly of all forms of cancer. The one that affects the colon is more frequent in women, and the rectal cancer is more common in men. In Nagoya University, Japan, a group of researchers from the School of Medicine has demonstrated that the pigment in purple corn impedes the development of cancer in the colon. In laboratory experiments, sample groups received food mixed with a natural cancerigenic substance which is found in the charred parts of roasted meat and fish, and another group also received 5% pigment of purple corn. In the group that was fed the cancer causing substance, 85% developed colon cancer, compared with only 40% that also received the pigment.

Research.

The results of several epidemiologic studies indicate that regular consumption of foods rich in polyphenolic compounds is associated with reduced risk of developing cardiovascular disease and certain cancers. Recent experimental studies in both animals and humans have shown that increasing polyphenol intake can protect LDL cholesterol from becoming oxidized (a key step in developing atherosclerosis), lower blood pressure in hypertensive subjects, reduce the tendency of the blood to clot and elevate total antioxidant capacity of the blood. After they are swallowed, anthocianins are easily detected in the blood. This was explained by Passamonti & col. (2003) who demonstrated that the stomach participates actively in the absorption of these compounds.

In a pre-clinical study, Tsuda & col. (2003) studied the effects of purple corn on obesity and diabetes. compared two sample groups. They consumed a diet rich in fats during 12 weeks, but one of the groups also received purple corn pigments. Compared with the control group the group consuming anthocyaninins didn’t gain any weight, nor suffered hypertrophy in the adiposites of the fat tissues, didn’t show hyperglycemia, hyperinsulinemia, hyperleptinemia, or increase in levels of the genetic codes that produce the factor or tumoral necrosis or the enzymes related to the synthesis of fatty acids and trilglicerol. In comparison, the group that didn’t receive the extract and ate only a fat rich diet, showed an increase of more than 100% in all those parameters. Thus, there are good nutritional and biochemical reasons to use the anthocianins present in purple corn, with obvious benefits for the prevention of obesity and diabetes.

It is known that the colon and rectum cancer is the second most deadly of all forms of cancer. The one that affects the colon is more frequent in women, and the rectal cancer is more common in men. In Nagoya University, Japan, a group of researchers from the School of Medicine has demonstrated that the pigment in purple corn impedes the development of cancer in the colon. In laboratory experiments, sample groups received food mixed with a natural cancerigenic substance which is found in the charred parts of roasted meat and fish, and another group also received 5% pigment of purple corn. In the group that was fed the cancer causing substance, 85% developed colon cancer, compared with only 40% that also received the pigment.

Anti-tumoral
Most flavonoids have anti-cancer properties.

Anti-oxidant
Digging deeper, the most abundant anthocyanin found in purple corn, induce the cellular antioxidant system.

References

1. FDA, Dept. of Health and Human Services. Code of Federal Regulations. Part 73. Listing of Color Additives Exempt from Certification. Sec. 73.169. Sec. 73.170. April 1, 2003.

2. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Kadota T, Koda T, Nakamura M, Imaida K, Ito N, Shirai T. Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett. 2001;171:17-25.

4 . Tsuda T, Horio F, Osawa T. Cyanidin 3-O-b-D-glucoside suppresses nitric oxide production during zymosan treatment in rats. J Nutr Sci Vitaminol. 2002;48(4):305-310.

5. Tsuda T, Horio F, Osawa T. Dietary cyanidin 3-O-? -D-6. Tsuda T, Horio F, Uchida K, Aoki H, Osawa T. Dietary cyanidin 3-O-? -D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr. 2003;133(7):2125-2130.

7. Tsuda T, Ueno Y, Aoki H, et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun. 2004;316:149-157.

Nutrient-Gene Interactions
Dietary Cyanidin 3-O-ß-D-Glucoside-Rich Purple Corn Color Prevents Obesity and Ameliorates Hyperglycemia in Mice
Takanori Tsuda1, Fumihiko Horio*, Koji Uchida{dagger}, Hiromitsu Aoki{dagger} and Toshihiko Osawa*

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Reference
The Journal for Nutrition:
http://jn.nutrition.org/cgi/content/full/133/7/2125
Doshisha de Kioto University
Japan
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Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan; * Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464-8601, Japan; and {dagger} San-Ei Gen F.F.I., Incorporated, Toyonaka, 561-8588, Japan

ABSTRACT
TOP
ABSTRACT
MATERIALS AND METHODS
RESULTS
DISCUSSION
LITERATURE CITED

Anthocyanins, which are used as a food coloring, are widely distributed in human diets, suggesting that we ingest large amounts of anthocyanins from plant-based foods. Mice were fed control, cyanidin 3-glucoside-rich purple corn color (PCC), high fat (HF) or HF + PCC diet for 12 wk. Dietary PCC significantly suppressed the HF diet–induced increase in body weight gain, and white and brown adipose tissue weights. Feeding the HF diet markedly induced hypertrophy of the adipocytes in the epididymal white adipose tissue compared with the control group. In contrast, the induction did not occur in the HF + PCC group. The HF diet induced hyperglycemia, hyperinsulinemia and hyperleptinemia. These perturbations were completely normalized in rats fed HF + PCC. An increase in the tumor necrosis factor (TNF)-{alpha} mRNA level occurred in the HF group and was normalized by dietary PCC. These results suggest that dietary PCC may ameliorate HF diet–induced insulin resistance in mice. PCC suppressed the mRNA levels of enzymes involved in fatty acid and triacylglycerol synthesis and lowered the sterol regulatory element binding protein-1 mRNA level in white adipose tissue. These down-regulations may contribute to triacylglycerol accumulation in white adipose tissue. Our findings provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes.

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