Search Results for: graviola

What’s in the fruit, seed and leaf?

The pulp contains 81% moisture, 3% titratable acidity and 24% non-reducing sugar. Graviola seed contains 8% moisture, 2% crude protein, 13% ash, 8% crude fiber, 20% fat and 47% carbohydrate. The seed also contains 0.2% water soluble ash, 0.8% titratable acidity and 17 mg calcium / 100 grams. There are quite a number of compounds in the fruit with exotic names. Some of these include acetogenins, muricins, annomuricine and muricapentocin, muricatocins A and B, and many others including annopentocins A, B, and C. The leaves contain monotetrahydrofuran acetogenins such as annomuricins A and B, gigantetrocin A, annonacin-10-one, muricatetrocins A and B, annonacin, and goniothalamicin.

Alternative Medicine provides new natural treatments

Graviola*
(Annona muricata )

Antitumoral, Anti cancer, hypotensive a powerful Peruvian herbal remedy (used actually as fruit) a recent research indicates that the antitumorous acetogenins are selectively toxic to just cancer cells.The annonacin is main natural active substance. Graviola may be used as a complementary therapy to cancer protocols.

Graviola contains Annonaceous Acetogenins which have remarkable cytotoxic, anti-tumor activities. Their research identified more than 40 compounds with anti-cancer properties capable of killing cancer cells. One of the compounds ‘bullatacin’ was reported to kill multi-resistant cells on human mammary cancer cells by inhibiting the production of an ATP (adenosine triphosphate) which is energy-carrying molecules found in the cells of all living things, that is essential to all cell processes.

In Peru there are several herbs used as anti-cancer, medicinal herbs or as an alternative cancer treatments, for example consider The Cats Claw, Camu Camu, Purple Corn and Graviola.

Annonaceous acetogenins are effective in killing tumors that have proven resistant to anti-cancer agents, but may also to destroy it

A Reserch Project held in Japan dated on on March 2002 discover various acetogenins found in several species of plants. They inoculated mice with lung cancer cells. One third received nothing (the control group), one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreated control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6% reduction of tumor mass over the control group—but 50% of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibited by 57.9%—slightly better than adriamycin—and without toxicity. This led the researchers to summarize;

“This suggested that annonacin was less toxic in mice. On considering the antitumor activity and toxicity, annonacin might be used as a lead to develop a potential anticancer agent.

The Annonaceous acetogenins discovered in graviola thus far include: annocatalin, annohexocin, annomonicin, annomontacin, annomuricatin A & B, annomuricin A thru E, annomutacin, annonacin, annonacinone, annopentocin A thru C, cis-annonacin, cis-corossolone, cohibin A thru D, corepoxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A & B, gigantetrocin, gigantetrocin A & B, gigantetrocinone, gigantetronenin, goniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muricatetrocin A & B muricatin D, muricatocin A thru C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I & IV, xylomaticin

Research, published in two separate journal articles,

References:

Kim, G. S., et al. “Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata.” J. Nat. Prod. 1998; 61(4): 432-36.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102-6.
Zeng, L., et al. “Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.” J. Nat. Prod. 1996; 59(11): 1035-42.
Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata.Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2001; 64(7): 925-31.
Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71 (2): 183-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-35.
Kim, G. S., et al. “Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.” Phytochemistry. 1998; 49(2): 565-71.” J. Nat. Prod. 1995; 58(6): 830-36.
Oberlies, N. H., et al. “Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay.” Cancer Lett. 1995; 96(1): 55-62.
Wu, F. E., et al. “Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(9): 1430-37.
Wu, F. E., et al. “New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 909-5.

Dossage: 2 tabs three times a day after two weeks discontinue the treatment for (2) days then re-start
*Do not be used during pregnancy.

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Proven Anti Cancer, Anti Tumoral Effects. It is effective in killing tumors that have proven resistant to anti-cancer agents. Other Actions Standard Dosage→ Read more

WEST LAFAYETTE, Ind. — The pawpaw (Graviola) tree, which bears the largest fruit native to North America, may bear new fruit forscientists seeking ways to fight cancer. Purdue University researcher Jerry McLaughlin, working with doctoral student Nicholas Oberlies, has found compounds in the bark of the tree that have shown preliminary success in fighting some drug-resistant cancers.The studies, published in two separate journal articles this summer, show that the pawpaw compounds not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells.

The findings were detailed in the journal Cancer Letters and the Journal of Medicinal Chemistry. Though further studies are needed to pinpoint exactly how the pawpaw compounds work within the cancer cell, McLaughlin says their effect is to pull the plug on the energy-producing mechanisms in the cell. McLaughlin notes, however, that the effect on drug-resistant cells has been studied only in laboratory cultures and will require additional study in animals before it can be tested in humans.”Multidrug-resistant cancer is hard to treat because the cancer cell has developed a mechanism to get around the anti-cancer agent,” says McLaughlin, professor of pharmacognosy in Purdue’s School of Pharmacy and Pharmacal Science. “Tumor cells that survive chemotherapy treatments often recover with increased resistance to the agent used in the original treatment program as well as to other related drugs.”

Such resistance can develop when surviving cancer cells develop one or more mechanisms to accelerate the removal of noxious substances, including anti-cancer drugs. One of the most common mechanisms used to circumvent the anti-cancer agents is to develop a “pump” that is capable of pushing anti-cancer agents out of the cell before they can kill it. These pumps are called P-glycoprotein mediated pumps and are named for the type of protein used to construct and operate them. Though all cells have the ability to develop such a pump, normal cells seldom do. Even in cancer cells, which do not respond normally to the body’s control mechanisms, only a small percentage of cells develop this pumping mechanism. “If having this pump was such a good deal, all cells would have it. But all cells don’t,” McLaughlin says. “In a given population of cancer cells in a person, maybe only 2 percent of the cancer cells possess this pump. But it’s those 2 percent of cancer cells that eventually grow and expand to create drug-resistant tumors.”

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One of the tricks currently attempted in treating cancer patients is to flood the body with other compounds to keep the pump busy, and then administer high doses of an anti-cancer agent in hopes that some of it will be able to stay in long enough to kill the cancer cell. “But the high doses of the drugs required for this treatment often produce side effects, such as loss of blood pressure, so the patient often succumbs to the side effects of the treatment,” McLaughlin says.Though this pump mechanism is efficient at eliminating most anti-cancer agents, McLaughlin, whose research group has identified more than 40 pawpaw compounds with anti-cancer properties, discovered a series of the compounds, called Annonaceous acetogenins, that were capable of killing cancer cells that employed this mechanism. He then designed a laboratory study to analyze the cytotoxic or cell-killing effects of one of the compounds, called bullatacin, on human mammary cancer cells. The study compared bullatacin’s effects on standard, nonresistant cancer cells and on multidrug-resistant cells.In the June issue of Cancer Letters, the research team reported that bullatacin prefere intially killed the multidrug-resistant cells by inhibiting the production of adenosine triphosphate, or ATP. ATP is a compound that works to release energy in acell and is essential to all cell processes. “A multidrug-resistant cell requires a tremendous amount of energy to run the pump and extrude things out of the cell,” McLaughlin says. “By inhibiting ATP production, we’re essentially pulling the plug on its energy source.”Though the pawpaw compounds also inhibited ATP production in noncancerous cells and nonresistant cancer cells, those cells were not affected as dramatically, McLaughlin says. Pawpaw shows promise in fighting drug-resistant tumors file: Purdue University News

“Normal cells and standard cancer cells may be able to minimize the effects of this compound because they don’t require the vast amounts of energy needed by the pump-running cells,” McLaughlin says. “The resistant cell is using its extra energy for this pump as well as to grow, so it is really taxed for energy. When we mess with the energy supply, it kills the cell.” McLaughlin and his group then did a follow-up study to test a series of 14 structurally similar pawpaw compounds to determine the structural features that maximize this biological activity in multidrug-resistant cancer cells. The results were published in the June issue of the Journal of Medicinal Chemistry. “This study tells us how to maximize this activity, so we have a pretty good idea what compounds we’d like to try in animals with multidrug-resistant tumors,” McLaughlin says. If proven effective in animals and humans, McLaughlin says, the compounds may be used to treat multidrug resistance in a variety of cancers, because many types of cancer cells develop resistance by employing a pump.The studies were funded by National Institutes of Health/National Cancer Institute, the Indiana Elks Cancer Research Fundantion, Purdue Research Foundation. Purdue has filed a patent on the use of the pawpaw compounds.

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Free Tecnical Report of Graviola Source: Jerry McLaughlin, (765) 494-1455; e-mail, jac@pharmacy.purdue.edu Writer: Susan Gaidos, (765) 494-2081; e-mail, susan_gaidos@uns.purdue.edu Purdue News Service: (765) 494-2096; e-mail, purduenews@uns.purdue.edu ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlinDepartment of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. ABSTRACT: J. Med. Chem. 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University. Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.

“10000 times stronger killer of Cancer than Chemo”.. do share it.. can save many lives, fill up hopes and build confidence in the patients..

The SourSop or the fruit from the graviola tree is a miraculous natural cancer cell killer 10,000 times stronger than Chemo.

Why are we not aware of this? It’s because some big corporation want to make back their money spent on years of research by trying to make a synthetic version of it for sale.

So, since you know it now you can help a friend in need by letting him know or just drink some soursop juice yourself as prevention from time to time. The taste is not bad after all. It’s completely natural and definitely has no side effects. If you have the space, plant one in your garden. The other parts of the tree are also useful. The next time you have a fruit juice, ask for a sour sop.

How many people died in vain while this billion-dollar drug maker concealed the secret of the miraculous Graviola tree? This tree is low and is called graviola in Brazil, guanabana in Spanish and has the uninspiring name “soursop” in English. The fruit is very large and the subacid sweet white pulp is eaten out of hand or, more commonly, used to make fruit drinks, sherbets and such.

The principal interest in this plant is because of its strong anti-cancer effects. Although it is effective for a number of medical conditions, it is its anti tumor effect that is of most interest. This plant is a proven cancer remedy for cancers of all types.

Besides being a cancer remedy, graviola is a broad spectrum antimicrobial agent for both bacterial and fungal infections, is effective against internal parasites and worms, lowers high blood pressure and is used for depression, stress and nervous disorders.

If there ever was a single example that makes it dramatically clear why the existence of Health Sciences Institute is so vital to Americans like you, it’s the incredible story behind the Graviola tree.

The truth is stunningly simple: Deep within the Amazon Rainforest grows a tree that could literally revolutionize what you, your doctor, and the rest of the world thinks about cancer treatment and chances of survival. The future has never looked more promising.

Research shows that with extracts from this miraculous tree it now may be possible to: * Attack cancer safely and effectively with an all-natural therapy that does not cause extreme nausea, weight loss and hair loss * Protect your immune system and avoid deadly infections * Feel stronger and healthier throughout the course of the treatment * Boost your energy and improve your outlook on life

The source of this information is just as stunning: It comes from one of America ‘s largest drug manufacturers, the fruit of over 20 laboratory tests conducted since the 1970′s! What those tests revealed was nothing short of mind numbing… Extracts from the tree were shown to:

* Effectively target and kill malignant cells in 12 types of cancer, including colon, breast, prostate, lung and pancreatic cancer. * The tree compounds proved to be up to 10,000 times stronger in slowing the growth of cancer cells than Adriamycin, a commonly used chemotherapeutic drug! * What’s more, unlike chemotherapy, the compound extracted from the Graviola tree selectively hunts down and kills only cancer cells. It does not harm healthy cells!

The amazing anti-cancer properties of the Graviola tree have been extensively researched–so why haven’t you heard anything about it? If Graviola extract is as half as promising as it appears to be–why doesn’t every single oncologist at every major hospital insist on using it on all his or her patients?

The spine-chilling answer illustrates just how easily our health–and for many, our very lives(!)–are controlled by money and power.

Graviola–the plant that worked too well

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One of America’s biggest billion-dollar drug makers began a search for a cancer cure and their research centered on Graviola, a legendary healing tree from the Amazon Rainforest.

Various parts of the Graviola tree–including the bark, leaves, roots, fruit and fruit-seeds–have been used for centuries by medicine men and native Indians in South America to treat heart disease, asthma, liver problems and arthritis. Going on very little documented scientific evidence, the company poured money and resources into testing the tree’s anti-cancerous properties–and were shocked by the results. Graviola proved itself to be a cancer-killing dynamo.

But that’s where the Graviola story nearly ended.

The company had one huge problem with the Graviola tree–it’s completely natural, and so, under federal law, not patentable. There’s no way to make serious profits from it.

It turns out the drug company invested nearly seven years trying to synthesize two of the Graviola tree’s most powerful anti-cancer ingredients. If they could isolate and produce man-made clones of what makes the Graviola so potent, they’d be able to patent it and make their money back. Alas, they hit a brick wall. The original simply could not be replicated. There was no way the company could protect its profits–or even make back the millions it poured into research.

As the dream of huge profits evaporated, their testing on Graviola came to a screeching halt. Even worse, the company shelved the entire project and chose not to publish the findings of its research!

Luckily, however, there was one scientist from the Graviola research team whose conscience wouldn’t let him see such atrocity committed. Risking his career, he contacted a company that’s dedicated to harvesting medical plants from the Amazon Rainforest and blew the whistle.

Miracle unleashed

When researchers at the Health Sciences Institute were alerted to the news of Graviola, they began tracking the research done on the cancer-killing tree. Evidence of the astounding effectiveness of Graviola–and its shocking cover-up–came in fast and furious….

….The National Cancer Institute performed the first scientific research in 1976. The results showed that Graviola’s “leaves and stems were found effective in attacking and destroying malignant cells.” Inexplicably, the results were published in an internal report and never released to the public…

…Since 1976, Graviola has proven to be an immensely potent cancer killer in 20 independent laboratory tests, yet no double-blind clinical trials–the typical benchmark mainstream doctors and journals use to judge a treatment’s value–were ever initiated…

A study published in the Journal of Natural Products, following a recent study conducted at Catholic University of South Korea stated that one chemical in Graviola was found to selectively kill colon cancer cells at “10,000 times the potency of (the commonly used chemotherapy drug) Adriamycin…”

The most significant part of the Catholic University of South Korea report is that Graviola was shown to selectively target the cancer cells, leaving healthy cells untouched. Unlike chemotherapy, which indiscriminately targets all actively reproducing cells (such as stomach and hair cells), causing the often devastating side effects of nausea and hair loss in cancer patients.

A study at Purdue University recently found that leaves from the Graviola tree killed cancer cells among six human cell lines and were especially effective against prostate, pancreatic and lung cancers. Seven years of silence broken–it’s finally here!

A limited supply of Graviola extract, grown and harvested by indigenous people in Brazil, is finally available in America.

The full Graviola Story–including where you can get it and how to use it–is included in Beyond Chemotherapy: New Cancer Killers, Safe as Mother’s Milk, a Health Sciences Institute FREE special bonus report on natural substances that will effectively revolutionize the fight against cancer. This crucial report (along with five more FREE reports) is yours ABSOLUTELY FREE with a new membership to the Health Sciences Institute. It’s just one example of how absolutely vital each report from the Institute can be to your life and those of your loved ones.

From breakthrough cancer and heart research and revolutionary Amazon Rainforest herbology to world-leading anti-aging research and nutritional medicine, every monthly Health Sciences Institute Member’s Alert puts in your hands today cures the rest of America –including your own doctor (!)–is likely to find out only ten years from now.

Uncaria Tormentosa Wild D.C. from Peru
A natural treatment for High Blood Pressure, Arthritis and even Cancer:

Discover the hidden power of the amazing Cats Claw roots.

Suggested for : Arthirtis, Rheumatism, muscles and joint problems, Hypertension, High blood pressure* and Even Cancer Treatments..

cat's claw peruvillage“Cat´s Claw (Uncaria tormentosa) is awoody vine from the tropical raiforest……………Cats Claw may lower blood pressure.”*

also helps with Joint pai rheumatoid arthritis as well as osteoarthritic Knee pain, and
it is consider a supr immune booster

(Tea´s bags and caps available also cream for external use)

Cat’s Claw is a tropical vine that grows in rainforest and jungle areas in Peru, South America and Asia. Some cultures refer to the plant as the “Sacred Herb of the Rain Forest”.

This vine gets its name from the small thorns at the base of the leaves, which looks like a cat’s claw. These claws enable the vine to attach itself around trees climbing to a heights up to 100 feet.

The plant is considered a valuable medicinal resource and is protected in Peru. Although scientific research has just recently begun to explore cat’s claw, many cultures native to the South American rain forest areas have used this herb for hundreds of years.

Current studies show it may have positive effects on, and can boost the body’s immune system. With recent fear of HIV, studies on cat’s claw have started to move quickly.

The active substances in Cat’s Claw are alkaloids, tannins and several other phytochemicals. Some of the alkaloids have been proven to boost the immune system. The major alkaloid rhynchophylline has anti-hypertensive effects and may reduce the risk of stroke and heart attack by lowering blood pressure, increasing circulation, reducing heart rate and controlling cholesterol.

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Other constituents contribute anti-inflammatory, antioxidant and anticancer properties. Many treatments combine the herb with different plants and natural products to increase the absorption and bioavailability.Cat’s Claw has long been used as a homeopathic treatment for intestinal ailments. Uses include: Crohn’s disease, gastric ulcers and tumors, parasites, colitis, gastritis, diverticulitis and leaky bowel syndrome.
By stimulating the immune system, it can also improve response to viral and respiratory infections. European clinical studies have used the extract from the bark in combination with AZT in the treatment of AIDS.

Cat´s Claw may help to reduce high blood pressure, according a recent research, see references*

It is also used in the treatment and prevention of arthritis and rheumatism, as well as diabetes, PMS, chronic fatigue syndrome, lupus, and prostrate conditions.

Tribal people in the regions where cat’s claw grows have used medicines prepared from the root bark for at least 2,000 years. They’ve used it to treat so many illnesses that it sounds like an amazing super drug. For example, sexually transmitted diseases, arthritis, ulcer, and cancer are all reported to be cured by cat’s claw.

After these claims drew the attention of scientists in Europe, tests were able to show that ingredients in cat’s claw have some potentially powerful qualities. Cat’s claw reportedly has immune stimulant and anti-inflammatory activity; it may be helpful for the treatment of colds, irritable bowel syndrome, diverticulitis, or Crohn’s disease. Much more research needs to be done on this plant and its medicinal properties. Still, cat’s claw ranked among the top 10 herbs sold in American natural food stores by 1997.

 

Dosage: 2 or 3 tea cups daily it is enough do not take exceed.(also tabs available)

Uncaria tomentosa), “Vilcacora”, “Cat’s claw” – Rubiaceae family
Parts used: Inner bark

Cat´s Claw (Uña de gato) is the most sacred herb among the Ashaninkas, Campo and some other Amazonian tribes. According to indigenous Shamans Uña de Gato serves as a bridge and balancer between the two worlds “physical and spiritual”; they believe in spiritual causes of ill health, they believe that firstly soul becomes ill then the body, the sacred balance/unity is broken, therefore Uña de Gato is helping to unify the two. They believe that greed and anger often causes cancer, fear causes Asthma, etc.

Klaus Keplinger (Austrian scientist) started analysis of Cat’s Claw properties in 1974.

Properties/Action/Usage in: cancer, HIV, AIDS, urinary track infection & inflammations, arthritis, rheumatism, sciatic nerve spasm, ulcers, tumors, very powerful immune system booster Studies indicate that cat’s claw has the ability to protect cancer cells from maturing but to destroy cancer cells that resistant to prescription medicines. The Graviola, another peruvian herbs suggested for these kind of diseases.

Note: It is advisable to clean out toxins and parasites to make herb usage more effective (see Fiber Buddy and Knock Out).

Cats Claw Cream.

Suggested for the topical treatment of arthritis, rheumatism, muscles and joint. problems

Contains Cats Claw peel extract equal to 6 grams o Cats Claw external use only. You an use the cream three times a day for seven days.

We do not recommend this product for pregnant woman or sensible or allergic patients.

* The Mayo Clinic a Guide for Alternative Medicine. The Time Inc Editor Brent Baur , M.D.

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