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BOTANICAL NAME: Cyclanthera pedata (L) Schrad.
COMMON NAME: Caigua or Caihua.
Caihua is derived from Perú and belongs to the Cucurbitaceas family, whose fruit is edible.

The fruit composition is:

Moisture: 93.00%
Protein : 0.49%
Fat: 0.20%
Fibre: 1.60%
Ashes: 1.00%
Nifex: 3.34%.

– Hypoglicemic effect .
– Hipotensive effect.
– Lipotropic effect.

– Cholesterol
– Obesity.

It is a native plant of Peru used for hundred years to prepare the creole meals such as “Guiso Caiga” or “Caigua Rellena”, but the ancient peruvians shamans (folklore medicine) uses the caigua for medicinal applications such as of high cholesterol, high blood pressure and weight loss the treatments.

Earlier studies demostrates that the Caigua as a sterols of vegetal origin (as for instance phytosterol) positively influence absorption of both cholesterols (endogenous and exogenous) reducing further risks dramatically of cholesterol Biosynthesis is of vital importance to the human organism, as it remains in many of our organs ( like the liver, skin, intestines and arterials) being therefore predecessor of many illnesses.

Hipercolosterolemia and/or hypertriglyceridemia are commonly related with the risk of coronary heart diseases, a risk that grows with age, but also during menopause in case of women.

The Peruvian ‘Instituto de Altura’ of the Cayetano Herédia University found evidence that ingestion of Caigua has corrected the cholesterol dramatically.

Other advanced studies demostrate how the high content of flavonoids may helt to reduce cholesterol.Most flavonoids have anti-germ activity. Immuno-Shield is an immune system product formulated by Dr. Sahelian that has flavonoids and several immune herbs and nutrients..

Most flavonoids have anti-cancer properties.


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Natural Antioxidant

Flavonoids are powerful antioxidants. Extracts from onion and various flavonoids induce the cellular antioxidant system. Onion extract and quercetin were able to increase the intracellular concentration of glutathione by approximately 50%.

High blood pressure

Caigua Research Update

Analysis of flavonoids from Cyclanthera pedata fruits by liquid chromatography/electrospray mass spectrometry.

This method is based on the separation of flavonoid glycosides present in the methanolic extracts from C. pedata fruits using high performance liquid chromatography (HPLC) followed by detection with electrospray ionization mass spectrometry (ESI/MS). Chromatographic separation of the analytes of interest was achieved on a Symmetry C-18 column with detection in positive ion mode. Calibration graphs were obtained by determining the area ratio between external standard of each major compound and the internal standard naringine. Due to the sensitivity and the repeatability of the assay, this method is suitable for industrial quality control of raw materials and final products.

Studies on the constituents of Cyclanthera pedata fruits: isolation and structure elucidation of new flavonoid glycosides and their antioxidant activity.J Agric Food Chem. 2001 Nov;49(11):5156-60.

Studies on the constituents of Cyclanthera pedata (Caigua): isolation and structure elucidation of new triterpenoid saponins.
J Agric Food Chem. 1999 Nov;47(11):4512-9.
The isolation of nine triterpenoid saponins (1-9), among them six new natural compounds (1-6), from the MeOH extract of the fruits of Cyclanthera pedata is reported. All of the structures were elucidated by spectroscopic methods, including the concerted application of one-dimensional (1)H-(1)H total correlation spectroscopy, (1)H-(1)H nuclear Overhauser effect spectroscopy), and (13)C-(13)C DEPT-NMR and two-dimensional NMR techniques (double-quantum filtered correlated spectroscopy, rotating-frame Overhauser enhancement spectroscopy, heteronuclear single quantum coherence, and heteronuclear multiple bond correlation). A comparative study of seeds and fruits has been also carried out.
An amazing Healthy Diet… Experts Say !

By Daniel DeNoon
WebMD Medical News Archive Reviewed By Brunilda Nazario, MD
on Wednesday, October 30, 2002

Oct. 30, 2002 — Pills made from dried Peruvian cucumber can help your heart, a supplement manufacturer claims. Now a prominent nutritionist says the claim may be true.

The pills are named as Caigua . They contain dried caigua — a hollow, cucumber-shaped plant from Peru. A small 1995 study by Peruvian doctors suggested that the pills cut “bad” LDL cholesterol levels by a third and raise “good” HDL cholesterol levels by more than a third.

Barbara Levine, PhD, co-director of the Human Nutrition Program at New York’s Rockefeller University, says this is a very impressive result. She hasn’t spoken with the Peruvian researchers but notes that their findings appeared in a respected journal — The Journal of the North American Menopause Society.

“What was interesting to me is it had a potent effect in raising HDL and lowering LDL,” Levine tells WebMD. “That is extensive for a dietary supplement. I have seen blood studies of patients in the U.S. who took Cycladol, and that is what we are seeing. This is really good. I do have a number of patients’ charts showing actual lipid effects, and it corroborates the study findings.”

Levine stresses that people who are taking cholesterol-lowering drugs should not switch to the supplement. And though she always advises people to check with a doctor before taking nutritional supplements, she says that Cycladol appears to be safe.

The 1995 study, by Gustavo F. Gonzales, MD, and colleagues of Peruana Cayetano Heridia University in Lima, Peru, found that it took daily doses of six caigua capsules to lower cholesterol. The study lasted 12 weeks.

“To my knowledge, there are no dietary supplements that lower cholesterol, but it would be great if there was one,” Lichtenstein tells WebMD. “I have a general rule: if a study isn’t replicated at least twice by independent labs, I remain skeptical. So if this was one 1995 study, if it was extremely efficacious somebody would have replicated by now.”

Meanwhile, Lichtenstein says that the best nutritional advice for people worried about cholesterol is to follow a heart-healthy diet. According to the American Heart Association, such a diet calls for:

* Limiting saturated fats to 7%-10% of the day’s total calories.
* Limiting total fats to 30% or less of the day’s total calories.
* Eating fewer than 300 milligrams of cholesterol a day.
* Limiting sodium intake to 2,400 milligrams a day.
* Asking a dietitian — or your doctor — to tell you the right number of daily calories you need to stay healthy and reduce your cholesterol.

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