Archive for the ‘Health & Nutrition News’ Category
WEST LAFAYETTE, Ind. — The pawpaw (Graviola) tree, which bears the largest fruit native to North America, may bear new fruit forscientists seeking ways to fight cancer. Purdue University researcher Jerry McLaughlin, working with doctoral student Nicholas Oberlies, has found compounds in the bark of the tree that have shown preliminary success in fighting some drug-resistant cancers.The studies, published in two separate journal articles this summer, show that the pawpaw compounds not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells.
The findings were detailed in the journal Cancer Letters and the Journal of Medicinal Chemistry. Though further studies are needed to pinpoint exactly how the pawpaw compounds work within the cancer cell, McLaughlin says their effect is to pull the plug on the energy-producing mechanisms in the cell. McLaughlin notes, however, that the effect on drug-resistant cells has been studied only in laboratory cultures and will require additional study in animals before it can be tested in humans.”Multidrug-resistant cancer is hard to treat because the cancer cell has developed a mechanism to get around the anti-cancer agent,” says McLaughlin, professor of pharmacognosy in Purdue’s School of Pharmacy and Pharmacal Science. “Tumor cells that survive chemotherapy treatments often recover with increased resistance to the agent used in the original treatment program as well as to other related drugs.”
Such resistance can develop when surviving cancer cells develop one or more mechanisms to accelerate the removal of noxious substances, including anti-cancer drugs. One of the most common mechanisms used to circumvent the anti-cancer agents is to develop a “pump” that is capable of pushing anti-cancer agents out of the cell before they can kill it. These pumps are called P-glycoprotein mediated pumps and are named for the type of protein used to construct and operate them. Though all cells have the ability to develop such a pump, normal cells seldom do. Even in cancer cells, which do not respond normally to the body’s control mechanisms, only a small percentage of cells develop this pumping mechanism. “If having this pump was such a good deal, all cells would have it. But all cells don’t,” McLaughlin says. “In a given population of cancer cells in a person, maybe only 2 percent of the cancer cells possess this pump. But it’s those 2 percent of cancer cells that eventually grow and expand to create drug-resistant tumors.”
One of the tricks currently attempted in treating cancer patients is to flood the body with other compounds to keep the pump busy, and then administer high doses of an anti-cancer agent in hopes that some of it will be able to stay in long enough to kill the cancer cell. “But the high doses of the drugs required for this treatment often produce side effects, such as loss of blood pressure, so the patient often succumbs to the side effects of the treatment,” McLaughlin says.Though this pump mechanism is efficient at eliminating most anti-cancer agents, McLaughlin, whose research group has identified more than 40 pawpaw compounds with anti-cancer properties, discovered a series of the compounds, called Annonaceous acetogenins, that were capable of killing cancer cells that employed this mechanism. He then designed a laboratory study to analyze the cytotoxic or cell-killing effects of one of the compounds, called bullatacin, on human mammary cancer cells. The study compared bullatacin’s effects on standard, nonresistant cancer cells and on multidrug-resistant cells.In the June issue of Cancer Letters, the research team reported that bullatacin prefere intially killed the multidrug-resistant cells by inhibiting the production of adenosine triphosphate, or ATP. ATP is a compound that works to release energy in acell and is essential to all cell processes. “A multidrug-resistant cell requires a tremendous amount of energy to run the pump and extrude things out of the cell,” McLaughlin says. “By inhibiting ATP production, we’re essentially pulling the plug on its energy source.”Though the pawpaw compounds also inhibited ATP production in noncancerous cells and nonresistant cancer cells, those cells were not affected as dramatically, McLaughlin says. Pawpaw shows promise in fighting drug-resistant tumors file: Purdue University News
“Normal cells and standard cancer cells may be able to minimize the effects of this compound because they don’t require the vast amounts of energy needed by the pump-running cells,” McLaughlin says. “The resistant cell is using its extra energy for this pump as well as to grow, so it is really taxed for energy. When we mess with the energy supply, it kills the cell.” McLaughlin and his group then did a follow-up study to test a series of 14 structurally similar pawpaw compounds to determine the structural features that maximize this biological activity in multidrug-resistant cancer cells. The results were published in the June issue of the Journal of Medicinal Chemistry. “This study tells us how to maximize this activity, so we have a pretty good idea what compounds we’d like to try in animals with multidrug-resistant tumors,” McLaughlin says. If proven effective in animals and humans, McLaughlin says, the compounds may be used to treat multidrug resistance in a variety of cancers, because many types of cancer cells develop resistance by employing a pump.The studies were funded by National Institutes of Health/National Cancer Institute, the Indiana Elks Cancer Research Fundantion, Purdue Research Foundation. Purdue has filed a patent on the use of the pawpaw compounds.Order Graviola
Free Tecnical Report of Graviola Source: Jerry McLaughlin, (765) 494-1455; e-mail, firstname.lastname@example.org Writer: Susan Gaidos, (765) 494-2081; e-mail, email@example.com Purdue News Service: (765) 494-2096; e-mail, firstname.lastname@example.org ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlinDepartment of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. ABSTRACT: J. Med. Chem. 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University. Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.
By James Meschino, DC, MS
In day-to-day practice, many practitioners encounter patients with hypertension problems that are not being managed effectively. Some patients in fact discontinue with their prescribed medications because of the undesirable side effects, or for other reasons.
As natural health practitioners, we are often asked if there are any dietary supplements or nutritional therapies that can lower blood pressure in a more natural way without producing unwanted side effects. Research studies conducted over the past 15 years support the use of specific dietary and supplementation practices, and participation in physical activity as natural interventions to reduce high blood pressure. In some cases these natural solutions are all that are required to control blood pressure; in other cases theses practices can significantly lower the requirement for medication, helping to reduce the likelihood of adverse side effects occurring from the use of these drugs.
Trends in Hypertension
High blood pressure affects approximately 25 percent of the adult population in developed countries such as the U.S. and Canada. In up to 75 percent of these cases, hypertension manifests in a mild form, which is highly sensitive to nutrition, supplementation and lifestyle practices.1,22 Even the most current medical literature stresses that people with documented hypertension should receive intensive nonpharmacologic therapies to improve control of their condition and reduce the risk of developing further cardiovascular disease.2 Hypertension, hypercholesterolemia and cigarette smoking are considered the cardinal risk factors for cardiovascular disease. Studies indicate that lowering a patient’s blood pressure from 160/90 to 140/80 mmHg may decrease risk of heart disease by more than 30 percent.3
From a medical standpoint, the use of anti-hypertensive drugs dominates the management of these conditions, and little attention is often given to nutrition and lifestyle approaches. However, many patients discontinue their drug regiment due to side effects from these drugs, which can include fatigue; male impotence; elevated cholesterol levels; light-headedness; dizziness; and skin eruptions.4 In Canada, 22 percent of adults have hypertension, but only 16 percent of this population is treated and controlled. This leaves 84 percent of hypertensive patients uncontrolled and sometimes unaware that this silent killer is even present.5,6 In general, hypertension across the population is not well controlled. An effort by alternative health care providers to help remedy this situation is urgently needed, as cardiovascular disease continues to be the leading cause of premature death in our society.
Effective Nutritional Therapies and Lifestyle Interventions (Please read about the Peruvian Caigua or Cyclantera Pedata to reduce cholesterol.)
Weight loss: Hypertensive patients who are overweight experience a drop to normal in their readings in approximately two-thirds of cases by simply losing 10-15 pounds.7,8 Overweight patients tend to display insulin resistance, especially in cases where there is a propensity for abdominal weight gain (android obesity). Insulin resistance results in higher secretion rates of insulin to help overcome the resistance to insulin displayed by peripheral body cells.
One of the consequences of hyperinsulinemia is increased retention of sodium by the kidneys, which tends to drive up blood pressure in sodium-sensitive individuals. Thus, moderate weight loss helps to reverse insulin resistance, lowering basal and postprandial insulin blood levels. This, in turn, encourages less sodium retention and a natural lowering of blood pressure. It is estimated that in up to half of adults in the U.S. whose hypertension is being pharmacologically managed, the need for drug therapy could be alleviated with only modest reductions in body weight.9
In conjunction with dietary advice to help reduce excess weight, engaging in regular endurance-based exercise (at least 40-60 minutes of brisk walking four to five times per week) has been shown to help reduce high blood pressure. Exercise further increases insulin sensitivity, accelerates weight loss and induces other changes within the cardiovascular system to lower blood pressure.6,10 Clearly, health practitioners should become more involved in providing patients with safe and effective nutrition and lifestyle practices that reverse weight gain and enhance the patient’s overall level of cardiovascular fitness.
Lower alcohol consumption: Studies indicate that excess alcohol consumption is a culprit in hypertension. Restricting alcohol consumption to two or fewer drinks per day, (fewer than 14 weekly for men, and nine for women) has been shown to help lower blood pressure in individuals who consume alcohol.7
Sodium restriction: Approximately 40-50 percent of hypertensive patients are thought to be sensitive to sodium intake, which is at least a partial cause of their problem. Salt sensitivity appears to be more common among blacks, diabetics and the elderly. Reducing sodium intake to 2000 mg per day is a prudent step in the global management of hypertension. This requires restricted use of discretionary salt, and avoiding heavily salted processed foods. (e.g., prepared soups, pickles, salted snack foods, foods containing MSG, etc.)7,11,12,13
Calcium supplementation: A number of well-designed human intervention trials reveal that calcium supplementation (1,000-1,500 mg calcium per day as calcium carbonate or citrate) can lower blood pressure, particularly in sodium-sensitive hypertensive patients. Calcium encourages sodium excretion by the kidneys and, in concert with magnesium, helps to relax the smooth muscle lining of arterioles, lowering diastolic pressure.11,14,35 Calcium and magnesium supplements are best taken with meals for this purpose, and to enhance their absorption.33
Magnesium supplementation: Supplementation with 600 mg per day of magnesium has been shown to lower blood pressure in some, but not all, studies. Presently, a greater body of evidence exists for calcium supplementation than for magnesium. However, there is no risk in including 600 mg of magnesium in the management of hypertension (unless severe kidney disease is present).15
Omega-3 Fat Supplementation: Over 60 double-blind studies have demonstrated that either fish oil or flaxseed oil supplementation can be effective in lowering blood pressure. One tablespoon per day of flaxseed oil can lower systolic and diastolic blood pressure by up to 9 mm Hg.16 I generally recommend 1,000 mg of flaxseed oil (in capsule form) twice a day with meals.
Garlic extract supplementation: Supplementation with a garlic extract product that yields 4,000 mcg of allicin (between a half and a whole clove of garlic) may help to lower blood pressure. Reductions of 20-30 mm Hg systolic and 10-20 mm Hg diastolic pressure have been demonstrated. However, this effect varies greatly among hypertensive subjects.2,17
Coenzyme Q10 supplementation: In recent years, a number of randomized, double-blind trials have demonstrated that Coenzyme Q10 (CoQ10) supplementation can effectively and consistently lower blood pressure in hypertensive subjects. CoQ10 is directly involved in the bioenergetic pathways of ATP production in heart muscle (myocardium). Research reveals that 39 percent of patients with high blood pressure have a deficiency of CoQ10. Supplementation with CoQ10 appears to correct this deficiency, correcting the underlying metabolic abnormality that leads to high blood pressure development.
Also the Peruvian Caigua it is an excellent herb to reduce the bad cholesterol, as well as the Yacon tea
Most experts in this field believe that CoQ10 is able to lower blood pressure through its favourable influence on heart bioenergetic mechanisms and possibly relaxing vascular smooth muscle. Because CoQ10 corrects an underlying metabolic defect that leads to high blood pressure, lowering of blood pressure usually requires four to 12 weeks of CoQ10 supplementation.18-21
In a recent randomized, double blind trial among patients receiving antihypertensive medications, the addition of 60 mg of CoQ10, twice daily was shown to markedly reduce both systolic and diastolic blood pressure. CoQ10 supplementation also reduced other risk factors for cardiovascular disease, including a lowering of fasting and two-hour plasma insulin, glucose, triglycerides, lipid peroxides and blood levels of malondialdehyde – a marker of free radical damage.
The authors of the study conclude that CoQ10 decreases blood pressure (possibly by decreasing oxidative stress, i.e., free radical generation) and insulin response in hypertension patients receiving conventional antihypertensive drugs. This study and others provide evidence that CoQ10 can be taken safely in conjunction with antihypertensive drugs to produce better blood pressure lowering outcomes. 22-24
The daily dosage of CoQ10 to aid in lowering blood pressure is usually 60 mg twice per day.22 A dosage of 100 mg once per day has been tested.16 In mild cases of hypertension, 30-75 mg once per day may be sufficient to normalize blood pressure.23,24
Hawthorn extract supplementation: The hawthorn plant and its berries are a rich source of a unique strand of bioflavonoids, known as procyanidins. Like CoQ10, these procyanidins have been shown to reverse congestive heart failure by enhancing bioenergetic pathways in the heart muscle (myocardium). More recently, we have seen a number of intervention trials that demonstrate that hawthorn extract supplementation can also effectively reduce high blood pressure.
The procyanidins in hawthorn act as cardiac glycoside agents that increase cyclic AMP and produce a vasodilatation effect on arteries. The daily dosage required to lower blood pressure ranges from 100-250 mg, up to three times daily if taken as a sole antihypertensive agent. To ensure sufficient levels of its active constituents (procyanidins), the product must be standardized to five-percent flavanoid content (1-2% vitexin content). Usually two to four weeks is required to see a significant decline in blood pressure in hypertensive patients.27 Hawthorn is contra-indicated in patients taking digitalis or digoxin.34
The World Health Organization has promoted lifestyle modification as an effective method of reducing high blood pressure and overall cardiovascular risk.24 A summary of effective natural antihypertensive interventions include:
Weight loss – Usually, only 10-15 lbs. of weight loss (in overweight subjects) will produce a significant blood pressure reduction in hypertensive patients.
Salt intake – Limit to 2-3 grams per day. Limit alcohol consumption to less than two drinks per day and even less for women. (maximum of nine drinks per week)
Exercise – endurance exercise 30-60 minutes per session a minimum of four times per week.
Calcium supplementation – 1,000-1,500 mg per day (calcium carbonate or citrate), taken in divided doses of 500 mg per dose (with food).
Magnesium supplementation – 600 mg per day (all at once or in divided doses, with food).
Flaxseed Oil – 2,000 mg per day (two 1,000-mg capsules with meals).
Coenzyme Q10 – 60 mg twice per day is a popular treatment for hypertension.
Hawthorn – 75 mg twice per day (standardized to five percent flavanoid content) can be used provided the patient is not also taking digitalis or digoxin.
Garlic extract supplementation (optional) – yielding 4,000 mcg of allicin content.
Fruits and vegetables – at least five servings per day.
The preceding recommendations can be used in conjunction with standard antihypertensive drugs, if necessary. At present, there is sufficient evidence from well-designed medical intervention trials to show that lifestyle interventions are successful in reducing or eliminating the need for pharmacologic therapy in a high percentage of hypertensive patients.29-32
For more information on this or other related topics, go to Dr. Meschino’s website at: www.renaisante.com.
1. Halpern S. (ed.) Quick reference to clinical nutrition. Nutrition and Cardiovascular Disease; J.B. Lippincott Company, Philadelphia, 1987:139-153.
2. Canadian Guidelines for Cardiac Rehabilitation and Cardiovascular Disease Prevention (Canadian Assoc. of Cardiac Rehab.) 1st edition, 1999;94-104.
3. Fowler FE. Myocardial infarction in the 1990s. Postgraduate Medicine May 1995;5:135-146.
4. Griffith HW. Complete Guide to Prescription and Non-Prescription Drugs (1999 edition) The Body Press 1998:168-169,194-195,54-55.
5. Murray CJLM, et al. Evidence-based health policy – lessons from the global burden of disease study. Science 1996;274:740-743.
6. Joffres MR, et al. Awareness, treatment, and control of hypertension in Canada. Am J Hypertens 1997;10(Pt-1):1097-1102.
7. 2000 Canadian hypertension recommendations (summary of recommendations affecting family physicians) – the Canadian Hypertension Recommendations Working Group. Canadian Family Physician. April 2001;47:793-794.
8. Goodhart R, Shils M, Lea, Febiger. Modern Nutrition in Health and Disease (sixth edition): 733.
9. McCarron D, et al. Body weight and blood pressure regulation. Am J Clin Nutr 1996; 63(suppl):423-425.
10. Pate RR, et al. Physical Activity and public health. JAMA Feb. 1, 1995;272,5:402-407.
11. McCarron D. Role of adequate dietary calcium intake in the prevention and management of salt-sensitive hypertension. Am J Clin Nutr 1997;62: 2(suppl):712-716.
12. Cappuccio F, et al. Double-blind randomized trial of modest salt restriction in older people. Lancet 1997;350;9081:850-854.
13. Graudal N, et al. Effects of sodium restriction on blood pressure, rennin, aldosterone, catecholamines, cholesterols, and triglycerides. JAMA 1998;279:1383-1391.
14. Meese RB, et al. The inconsistent effects of calcium supplements upon blood pressure in primary hypertension. Am J Med Sci 1987;29:4219-4224.
15. Motoyama T, et al. Oral magnesium supplementation in patients with essential hypertension. Hypertension1989;13:227-232.
16. Murray M, Pizzorno J. Encyclopedia of Natural Medicine (2nd edition) Prima Publishing 1997;425-535.
17. Foushee DB, et al. Garlic as a natural agent for the treatment of hypertension. A preliminary report. Cytobios 1982;34:145-162.
18. Digiesi V, et al. Mechanism of action of Coenzyme Q10 in essential hypertension. Curr Ther Res 1992;Res 51:668-672.
19. Langsjoen P, et al. Treatment of essential hypertension with Coenzyme Q10. Mol Aspects Med 1994 Med 15 (suppl):265-272.
20. Digiesi V, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994; Med 15 (suppl):257-263.
21. McCarty MF. Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation? Med Hypotheses 1999;53,4:300-304.
22. Singh RB, et al. Effect of hydrosoluble Coenzyme Q10 on blood pressure and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13,3:203-208.
23. Yamagami T, et al. Bioenergetics in clinical medicine: studies on coenzyme Q10 and essential hypertension. Research Comm. in Chem. Path and Pharmacol 1975;11,2: 273-288.
24. Yamagami T, et al. Bioenergetics in clinical medicine, VIII. Administration of Coenzyme Q10 to patients with essential hypertension. Research Comm in Chem Path and Pharmacol 1976;14,4:721-727.
25. Murray M. Encyclopedia of Nutritional Supplements. PRIMA publishing 1996:300-301.
26. Werbach MR. Nutritional Influences on Illness. Third Line Press, Inc. 1987:227-240.
27. Murray M, Pizzorno J. Encyclopedia of Natural Medicine (2nd edit) Prima Publishing 1997:524-535.
28. Petrella RJ. Lifestyle approaches to managing high blood pressure. Can Family Phys 1999;45:1750-1755.
29. Elmer JP, et al. Lifestyle intervention: results of the Treatment of Mild Hypertension study. (TOHMS). Prev Med 1995;24:378-388.
30. Stamler R, et al. Nutritional therapy for high blood pressure. Final report of a four-year randomized controlled trial – the hypertension control program. JAMA 1987;257:1484-1491.
31. Iso H, et al. Community-based education classes for hypertension control: a 1.5-year randomized controlled trial. Hypertension 1996;27:968-974.
32. Appel LJ, et al. A clinical trial of the effects of dietary patterns on blood pressure (DASH-study) N Engl J Med 1997;336:1117-1124.
33. Levenson D, et al. A review of calcium preparations. Nutr Reviews 1994;52,7:221-232.
34. Shariff S, et al. Herbal fervor and vitamin vigor: Herbs and vitamins for cardiac disease. Perspective in Cardiology 2000;16,1:21-29.
35. McCarron D, et al. Blood pressure response to oral calcium in persons with mild to moderate hypertension. A randomized, double-blind, placebo-controlled, crossover trial. Ann Intern Med 1985;03,6:825-831.
James Meschino,DC,MS Toronto, Ontario Canada
Alternative medicine as the Cats Claw have been used for thousand years by ancient Peruvians as a natural medicine for several diseases such as arthritis, joint pain. Cats Claw is a powerful natural anti-inflamatory herb and it is totally safe and does not have side effects as many prescription medicine.
Cat’s Claw (Tea´s bags and caps available)
Cat’s Claw is a tropical vine that grows in rainforest and jungle areas in South America and Asia. Some cultures refer to the plant as the “Sacred Herb of the Rain Forest”.
This vine gets its name from the small thorns at the base of the leaves, which looks like a cat’s claw. These claws enable the vine to attach itself around trees climbing to a heights up to 100 feet.
The plant is considered a valuable medicinal resource and is protected in Peru. Although scientific research has just recently begun to explore cat’s claw, many cultures native to the South American rain forest areas have used this herb for hundreds of years.
Current studies show it may have positive effects on, and can boost the body’s immune system. With recent fear of HIV, studies on cat’s claw have started to move quickly.
The active substances in Cat’s Claw are alkaloids, tannins and several other phytochemicals. Some of the alkaloids have been proven to boost the immune system. The major alkaloid rhynchophylline has anti-hypertensive effects and may reduce the risk of stroke and heart attack by lowering blood pressure, increasing circulation, reducing heart rate and controlling cholesterol.
Other constituents contribute anti-inflammatory, antioxidant and anticancer properties. Many treatments combine the herb with different plants and natural products to increase the absorption and bioavailability. Cat’s Claw has long been used as a homeopathic treatment for intestinal ailments. Uses include: Crohn’s disease, arthritis, joint pain, osteoarthritis, gastric ulcers and tumors, parasites, colitis, gastritis, diverticulitis and leaky bowel syndrome.
By stimulating the immune system, it can also improve response to viral and respiratory infections. European clinical studies have used the extract from the bark in combination with AZT in the treatment of AIDS.
It is also used in the treatment and prevention of arthritis and rheumatism, as well as diabetes, PMS, chronic fatigue syndrome, lupus, and prostrate conditions.
Tribal people in the regions where cat’s claw grows have used medicines prepared from the root bark for at least 2,000 years. They’ve used it to treat so many illnesses that it sounds like an amazing super drug.For example, sexually transmitted diseases, arthritis, ulcer, and cancer are all reported to be cured by cat’s claw.
After these claims drew the attention of scientists in Europe, tests were able to show that ingredients in cat’s claw have some potentially powerful qualities. Cat’s claw reportedly has immune stimulant and anti-inflammatory activity; it may be helpful for the treatment of colds, irritable bowel syndrome, diverticulitis, or Crohn’s disease. Much more research needs to be done on this plant and its medicinal properties. Still, cat’s claw ranked among the top 10 herbs sold in American natural food stores by 1997.
Dosage: 2 or 3 tea cups daily it is enough do not take exceed.(also tabs available)
Uncaria tomentosa), “Vilcacora”, “Cat’s claw” – Rubiaceae family Parts used: Inner bark
Uña de gato is the most sacred herb among the Ashaninkas, Campo and some other Amazonian tribes. According to indigenous Shamans Uña de Gato serves as a bridge and balancer between the two worlds “physical and spiritual”; they believe in spiritual causes of ill health, they believe that firstly soul becomes ill then the body, the sacred balance/unity is broken, therefore Uña de Gato is helping to unify the two. They believe that greed and anger often causes cancer, fear causes Asthma, etc.
Klaus Keplinger (Austrian scientist) started analysis of Cat’s Claw properties in 1974.
Properties/Action/Usage in: cancer, HIV, AIDS, urinary track infection & inflammations, arthritis, rheumatism, sciatic nerve spasm, ulcers, tumors, very potent immune system booster Studies indicate that cat’s claw has the ability to protect cancer cells from maturing. For more info click here.
Note: It is advisable to clean out toxins and parasites to make herb usage more effective (see Fiber Buddy and Knock Out). Do not suggested for those with digestive problems such as gasthritis.Order Cat's Claw
“10000 times stronger killer of Cancer than Chemo”.. do share it.. can save many lives, fill up hopes and build confidence in the patients..
The SourSop or the fruit from the graviola tree is a miraculous natural cancer cell killer 10,000 times stronger than Chemo.
Why are we not aware of this? It’s because some big corporation want to make back their money spent on years of research by trying to make a synthetic version of it for sale.
So, since you know it now you can help a friend in need by letting him know or just drink some soursop juice yourself as prevention from time to time. The taste is not bad after all. It’s completely natural and definitely has no side effects. If you have the space, plant one in your garden. The other parts of the tree are also useful. The next time you have a fruit juice, ask for a sour sop.
How many people died in vain while this billion-dollar drug maker concealed the secret of the miraculous Graviola tree? This tree is low and is called graviola in Brazil, guanabana in Spanish and has the uninspiring name “soursop” in English. The fruit is very large and the subacid sweet white pulp is eaten out of hand or, more commonly, used to make fruit drinks, sherbets and such.
The principal interest in this plant is because of its strong anti-cancer effects. Although it is effective for a number of medical conditions, it is its anti tumor effect that is of most interest. This plant is a proven cancer remedy for cancers of all types.
Besides being a cancer remedy, graviola is a broad spectrum antimicrobial agent for both bacterial and fungal infections, is effective against internal parasites and worms, lowers high blood pressure and is used for depression, stress and nervous disorders.
If there ever was a single example that makes it dramatically clear why the existence of Health Sciences Institute is so vital to Americans like you, it’s the incredible story behind the Graviola tree.
The truth is stunningly simple: Deep within the Amazon Rainforest grows a tree that could literally revolutionize what you, your doctor, and the rest of the world thinks about cancer treatment and chances of survival. The future has never looked more promising.
Research shows that with extracts from this miraculous tree it now may be possible to: * Attack cancer safely and effectively with an all-natural therapy that does not cause extreme nausea, weight loss and hair loss * Protect your immune system and avoid deadly infections * Feel stronger and healthier throughout the course of the treatment * Boost your energy and improve your outlook on life
The source of this information is just as stunning: It comes from one of America ‘s largest drug manufacturers, the fruit of over 20 laboratory tests conducted since the 1970′s! What those tests revealed was nothing short of mind numbing… Extracts from the tree were shown to:
* Effectively target and kill malignant cells in 12 types of cancer, including colon, breast, prostate, lung and pancreatic cancer. * The tree compounds proved to be up to 10,000 times stronger in slowing the growth of cancer cells than Adriamycin, a commonly used chemotherapeutic drug! * What’s more, unlike chemotherapy, the compound extracted from the Graviola tree selectively hunts down and kills only cancer cells. It does not harm healthy cells!
The amazing anti-cancer properties of the Graviola tree have been extensively researched–so why haven’t you heard anything about it? If Graviola extract is as half as promising as it appears to be–why doesn’t every single oncologist at every major hospital insist on using it on all his or her patients?
The spine-chilling answer illustrates just how easily our health–and for many, our very lives(!)–are controlled by money and power.
Graviola–the plant that worked too well
One of America’s biggest billion-dollar drug makers began a search for a cancer cure and their research centered on Graviola, a legendary healing tree from the Amazon Rainforest.
Various parts of the Graviola tree–including the bark, leaves, roots, fruit and fruit-seeds–have been used for centuries by medicine men and native Indians in South America to treat heart disease, asthma, liver problems and arthritis. Going on very little documented scientific evidence, the company poured money and resources into testing the tree’s anti-cancerous properties–and were shocked by the results. Graviola proved itself to be a cancer-killing dynamo.
But that’s where the Graviola story nearly ended.
The company had one huge problem with the Graviola tree–it’s completely natural, and so, under federal law, not patentable. There’s no way to make serious profits from it.
It turns out the drug company invested nearly seven years trying to synthesize two of the Graviola tree’s most powerful anti-cancer ingredients. If they could isolate and produce man-made clones of what makes the Graviola so potent, they’d be able to patent it and make their money back. Alas, they hit a brick wall. The original simply could not be replicated. There was no way the company could protect its profits–or even make back the millions it poured into research.
As the dream of huge profits evaporated, their testing on Graviola came to a screeching halt. Even worse, the company shelved the entire project and chose not to publish the findings of its research!
Luckily, however, there was one scientist from the Graviola research team whose conscience wouldn’t let him see such atrocity committed. Risking his career, he contacted a company that’s dedicated to harvesting medical plants from the Amazon Rainforest and blew the whistle.
When researchers at the Health Sciences Institute were alerted to the news of Graviola, they began tracking the research done on the cancer-killing tree. Evidence of the astounding effectiveness of Graviola–and its shocking cover-up–came in fast and furious….
….The National Cancer Institute performed the first scientific research in 1976. The results showed that Graviola’s “leaves and stems were found effective in attacking and destroying malignant cells.” Inexplicably, the results were published in an internal report and never released to the public…
…Since 1976, Graviola has proven to be an immensely potent cancer killer in 20 independent laboratory tests, yet no double-blind clinical trials–the typical benchmark mainstream doctors and journals use to judge a treatment’s value–were ever initiated…
A study published in the Journal of Natural Products, following a recent study conducted at Catholic University of South Korea stated that one chemical in Graviola was found to selectively kill colon cancer cells at “10,000 times the potency of (the commonly used chemotherapy drug) Adriamycin…”
The most significant part of the Catholic University of South Korea report is that Graviola was shown to selectively target the cancer cells, leaving healthy cells untouched. Unlike chemotherapy, which indiscriminately targets all actively reproducing cells (such as stomach and hair cells), causing the often devastating side effects of nausea and hair loss in cancer patients.
A study at Purdue University recently found that leaves from the Graviola tree killed cancer cells among six human cell lines and were especially effective against prostate, pancreatic and lung cancers. Seven years of silence broken–it’s finally here!
A limited supply of Graviola extract, grown and harvested by indigenous people in Brazil, is finally available in America.
The full Graviola Story–including where you can get it and how to use it–is included in Beyond Chemotherapy: New Cancer Killers, Safe as Mother’s Milk, a Health Sciences Institute FREE special bonus report on natural substances that will effectively revolutionize the fight against cancer. This crucial report (along with five more FREE reports) is yours ABSOLUTELY FREE with a new membership to the Health Sciences Institute. It’s just one example of how absolutely vital each report from the Institute can be to your life and those of your loved ones.
From breakthrough cancer and heart research and revolutionary Amazon Rainforest herbology to world-leading anti-aging research and nutritional medicine, every monthly Health Sciences Institute Member’s Alert puts in your hands today cures the rest of America –including your own doctor (!)–is likely to find out only ten years from now.